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KMID : 0931320080080020103
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대한상부위장관.헬리코박터학회지
2008 Volume.8 No. 2 p.103 ~ p.107
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Histological Differences of Surrounding Mucosa according to Helicobacter pylori Infection and Preexisting Adenoma in Early Gastric Cancer
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Kang Hyoun-Woo
Kang Hae-Yeon
Kim Sang-Gyun
Kim Joo-Sung
Jung Hyun-Chae
Song In-Sung
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Abstract
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Background/Aims: Helicobacter pylori (HP), atrophy, intestinal metaplasia (IM) and gastric adenoma are known to be the risk factors of gastric cancer. The aim of this study was to find histological risk factors by comparing grades of atrophy and IM of background mucosa according to HP infection and preexisting adenoma (PA).
Methods: We investigated 670 patients who had undergone endoscopic submucosal dissection due to gastric adenoma or early gastric cancer (EGC) in Seoul National University Hospital between August 2005 and November 2007. They were divided into 6 groups according to status of tumor, HP infection and preexisting adenoma. The grades of atrophy and IM at midbody and antrum were evaluated by updated Sydney grading system.
Results: Age and mean tumor size were larger in PA (＋) EGC than the other group. Mean grades of atrophy and IM in antrum and body were higher in PA (＋) EGC group than in PA (?) EGC group regardless of HP infection. In addition, mean grades of corporeal atrophy and IM were higher PA (＋) EGC group than in adenoma group.
Conclusions: Atrophy and IM of surrounding mucosa were more severe in gastric cancer with preexisting adenoma than in that without preexisting adenoma.
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KEYWORD
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Helicobacter pylori, Atrophy, Intestinal metaplasia, Preexisting adenoma, Early gastric cancer
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